Alpha-arylethylpiperazine derivatives as neurokinin antagonists

The invention relates to new alpha -arylethylpiperazine derivatives, which are useful as neurokinin receptor antagonists (NK1antagonists). It also relates to processes for the preparation of said alpha -arylethylpiperazine derivatives, to their use for the prevention and/or treatment of a condition...

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Main Authors MICHEL NEUWELS, FLORENCE MOUREAU, FRANCOISE STIERNET, MARIE-AGNES LASSOIE, THOMAS RYCKMANS, SOLO GOLDSTEIN, CHRISTOPHE GENICOT, THIERRY TAVERNE, JEAN-PIERRE HENICHART
Format Patent
LanguageEnglish
Published 03.07.2001
Edition7
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new alpha -arylethylpiperazine derivatives, which are useful as neurokinin receptor antagonists (NK1antagonists). It also relates to processes for the preparation of said alpha -arylethylpiperazine derivatives, to their use for the prevention and/or treatment of a condition associated with pathogical levels of substance P in a patient and to pharmaceutical compositions containing them.
Bibliography:Application Number: AU2673201