Solid support synthesis of 2-oxopiperazines

The subject invention involves processes for making 2-oxopiperazine and homologous compounds using a solid support resin by (a) removing the protecting group from an N-protected amino acid ester of the resin (if present), (b) reacting the resulting unprotected resin ester with a N-protected alpha -a...

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Bibliographic Details
Main Authors ADAM GOLEBIOWSKI, SEAN REES KLOPFENSTEIN
Format Patent
LanguageEnglish
Published 15.09.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The subject invention involves processes for making 2-oxopiperazine and homologous compounds using a solid support resin by (a) removing the protecting group from an N-protected amino acid ester of the resin (if present), (b) reacting the resulting unprotected resin ester with a N-protected alpha -amino aldehyde, (c) optionally modifying the resulting intermediate by substituting a non-hydrogen moiety on the N from the amino acid, (d) removing the remaining N-protecting group from the N from the amino aldehyde, and (e) cleaving/cyclizing the product from the resin.
Bibliography:Application Number: AU19990025939