Solid support synthesis of 2-oxopiperazines
The subject invention involves processes for making 2-oxopiperazine and homologous compounds using a solid support resin by (a) removing the protecting group from an N-protected amino acid ester of the resin (if present), (b) reacting the resulting unprotected resin ester with a N-protected alpha -a...
Saved in:
Main Authors | , |
---|---|
Format | Patent |
Language | English |
Published |
15.09.1999
|
Edition | 6 |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The subject invention involves processes for making 2-oxopiperazine and homologous compounds using a solid support resin by (a) removing the protecting group from an N-protected amino acid ester of the resin (if present), (b) reacting the resulting unprotected resin ester with a N-protected alpha -amino aldehyde, (c) optionally modifying the resulting intermediate by substituting a non-hydrogen moiety on the N from the amino acid, (d) removing the remaining N-protecting group from the N from the amino aldehyde, and (e) cleaving/cyclizing the product from the resin. |
---|---|
Bibliography: | Application Number: AU19990025939 |