SOMATOSTATIN ANALOGUES

Novel peptides, which are pharmaceutically useful, of the formula II and the non-toxic salts thereof, are obtained by linking the individual amino acids to form a peptide intermediate of the formula III in which the substituents are defined in claim 1, eliminating the protective group or the protect...

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Bibliographic Details
Main Authors WYLIE WALKER VALE, JR, MARVIN ROSS BROWN, JEAN EDOUARD FREDERIC RIVIER
Format Patent
LanguageEnglish
Published 07.12.1978
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel peptides, which are pharmaceutically useful, of the formula II and the non-toxic salts thereof, are obtained by linking the individual amino acids to form a peptide intermediate of the formula III in which the substituents are defined in claim 1, eliminating the protective group or the protective groups from the intermediate compound of the formula III, and, if X5 denotes a resin support, cleaving off the peptide from the resin and, where appropriate, preparing the non-toxic salts from resulting compounds. The peptides prepared in this way can be oxidised in order to form a disulphide bond between the said Cys residues. The novel peptides, which can be prepared in accordance with the invention, possess a specific effect in relation to stemming the release of insulin and glucagon in connection with the treatment of diabetes.
Bibliography:Application Number: AU19770025775