A method of inducing cholecystokinin agonist activity using 1,4-benzodiazepine compounds

PCT No. PCT/EP95/01335 Sec. 371 Date Oct. 11, 1996 Sec. 102(e) Date Oct. 11, 1996 PCT Filed Apr. 13, 1995 PCT Pub. No. WO95/28399 PCT Pub. Date Oct. 26, 1995A method of inducing a Cholescystokinin-A receptor agonist response in a mammal by administering a compound of formula (I), (I) where R1 is C1-...

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Main Authors TIMOTHY MARK WILLSON, ELIZABETH ELLEN SUGG, MILANA DEZUBE, RONALD GEORGE SHERRILL, JERZY RYSZARD SZEWCZYK, CHRISTOPHER JOSEPH AQUINO
Format Patent
LanguageEnglish
Published 10.11.1995
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/EP95/01335 Sec. 371 Date Oct. 11, 1996 Sec. 102(e) Date Oct. 11, 1996 PCT Filed Apr. 13, 1995 PCT Pub. No. WO95/28399 PCT Pub. Date Oct. 26, 1995A method of inducing a Cholescystokinin-A receptor agonist response in a mammal by administering a compound of formula (I), (I) where R1 is C1-C6alkyl, C3-6cycloalkyl, phenyl, or substituted phenyl; R2 is C3-6alkyl, C3-6cycloalkyl, C3-6alkenyl, benzyl, phenylC1-3alkyl or substituted phenyl; or NR1R2 together form 1,2,3,4-tetrahydroquinoline or benzazepine mono-, di-, or trisubstituted independently with C1-6alkyl, C1-6alkoxy or halogen substituents; n is an integer selected from the grouping consisting of 0,1,2 or 3; p is the integer 0 or 1; q is the integer 0 or 1; r is the integer 0 or 1, provided that when q is 0 then r is 0; R3, R4, R5 and R8 are selected from a variety of substituents; X is nitrogen, nitroso or R8; m is an integer selected from the group consisting of 0, 1, 2 or 3; Y and Z are hydrogen or halogen, novel intermediates, a pharmaceutical composition for treating obesity, gall bladder stasis, disorders of pancreatic secretion, methods for such treatment and processes for preparing compounds of formula (I).
Bibliography:Application Number: AU19950024462