CEPHALOSPORIN DERIVATIVES WITH IMPROVED PHARMACOKINETICS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION IN WHICH THEY ARE PRESENT AND SYNTHESIS INTERMEDIATE

New cephalosporin derivatives of formula: in which: - each of R1, R2 and R3 denotes a hydrogen atom or each of R1 and R2 denotes a hydrogen atom or a methyl group and R3 denotes a carboxyl group, or R1 and R2 taken together with the carbon atom to which they are linked form a cyclobutyl nucleus and...

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Bibliographic Details
Main Authors ALI SALHI, BERNARD LABEEUW
Format Patent
LanguageEnglish
Published 13.04.1989
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:New cephalosporin derivatives of formula: in which: - each of R1, R2 and R3 denotes a hydrogen atom or each of R1 and R2 denotes a hydrogen atom or a methyl group and R3 denotes a carboxyl group, or R1 and R2 taken together with the carbon atom to which they are linked form a cyclobutyl nucleus and R3 denotes a carboxyl group, - the 2 groups A are different: one denotes a hydroxyl group and the other denotes a -NH-SO2-Alk-NH2 group in which Alk denotes a C2-C4 lower alkylene group, and the pharmaceutically acceptable salts and esters of the said derivatives. The invention also relates to a process for their preparation, pharmaceutical compositions containing them and synthesis intermediates. The said derivatives exhibit improved pharmacokinetic properties.
Bibliography:Application Number: AU19880023495