USE OF A URINARY BLADDER ECM HYDROGEL AS AN ESOPHAGEAL SUBMUCOSAL FLUID CUSHION

Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of the esophagus of a subject. These methods include injecting submucosally into the region of the esophagus of the subject a pharmaceutical composition comprising a urinary bladder extracellular ma...

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Bibliographic Details
Main Authors Naranjo Gutierrez, Juan Diego, Badylak, Stephen Francis, Saldin, Lindsey Tamiko
Format Patent
LanguageEnglish
Published 26.09.2024
Subjects
CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Methods are disclosed for dissecting a mucosa and a submucosa from a muscularis propria from a region of the esophagus of a subject. These methods include injecting submucosally into the region of the esophagus of the subject a pharmaceutical composition comprising a urinary bladder extracellular matrix (ECM) hydrogel, to form a cushion between the submucosa and the underlying muscularis propria at the region of the esophagus, wherein the ECM hydrogel has the following characteristics: a) a time to 50% gelation of less than 20 minutes at a temperature of about 37°C; b) a flow viscosity suitable for infusion into the esophagus; and c) a stiffness of about 10 to about 400 Pascal (Pa).
Bibliography:Application Number: AU20240219503