ANTIBODY-DRUG CONJUGATE COMPRISING ANTIBODY AGAINST HUMAN ROR1, AND USE FOR THE SAME

• Main Authors: KIM, Sung Min, YANG, Young-Jae, PARK, Kyungjin, KIM, Hyoung Rae, YEOM, Donghoon, BAEK, Ju Yuel, PARK, Minji, RYU, Hyun Min, CHAE, Jeiwook, SONG, Daehae, SUNG, Byungje, JUNG, Jinwon, KIM, Juhee, LEE, Yangsoon, KANG, Dae Hyuck, HAN, Nara, PARK, Yun Hee, LEE, Chang Sun, YOU, Ji-Na, LEE, Bora, EOM, Jaehyun, AHN, Jinhyung, PARK, Kyung Eun, KIM, Yong Zu, YOO, Jiseon, HONG, Youngeun, OH, Ji Hye, LEE, Ju Young, LEE, Hyeun Joung, SONG, Ho Young
• Format: Patent
• Language: English
• Published: 29.08.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Abstract The present invention relates to new antibody-drug conjugates (ADCs) targeting RORI, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically diseases associated with over-expression of RORI, for example cancer. More specifically, the present invention relates to an antibody-drug conjugate comprising an antibody that binds to ROR1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.