Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors

The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) Ar-Z Het (I) 5 wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates t...

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Main Authors BREHMER, Dirk, VIELLEVOYE, Marcel, MEERPOEL, Lieven, THURING, Johannes Wilhelmus John F, SUN, Weimei, BEKE, Lijs, WU, Tongfei, PANDE, Vineet, PARADE, Marcus Cornelis Bernardus Catharina, DIELS, Gaston Stanislas Marcella, BOECKX, An, LAWSON, Edward Charles, GILISSEN, Ronaldus Arnodus Hendrika Joseph, SCHEPENS, Wim Bert Griet
Format Patent
LanguageEnglish
Published 18.04.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) Ar-Z Het (I) 5 wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
Bibliography:Application Number: AU20240202052