Controlled-release CNP agonists with increased NEP stability

Abstract The present invention relates to controlled-release CNP agonists having an at least 5-fold longer degradation half-life in an in vitro NEP degradation assay than the corresponding released CNP agonist, to pharmaceutical compositions comprising said controlled-release CNP agonist, their use...

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Bibliographic Details
Main Authors Hersel, Ulrich, Rau, Harald, Sprogøe, Kennett, Bernhard, Ana, Wegge, Thomas, Cleemann, Felix
Format Patent
LanguageEnglish
Published 22.02.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Abstract The present invention relates to controlled-release CNP agonists having an at least 5-fold longer degradation half-life in an in vitro NEP degradation assay than the corresponding released CNP agonist, to pharmaceutical compositions comprising said controlled-release CNP agonist, their use and to methods of treatment.
Bibliography:Application Number: AU20240200659