Methods and reagents for analyzing protein-protein interfaces

Abstract The present disclosure provides compounds comprising a presenter protein binding moiety (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) or a target protein binding moiety and a cross-linker group; compositions of the compounds; their conjugates and complexes...

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Bibliographic Details
Main Authors Shigdel, Uddhav Kumar, Verdine, Gregory L, Anthony, Neville J, Lee, Seung-Joo, Nichols, M. James, Townson, Sharon A, Stiles, Dylan T
Format Patent
LanguageEnglish
Published 08.02.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Abstract The present disclosure provides compounds comprising a presenter protein binding moiety (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) or a target protein binding moiety and a cross-linker group; compositions of the compounds; their conjugates and complexes; and related methods for determining the structure of a complex or the interface in a complex therewith. In some embodiments, the target and/or presenter proteins are intracellular proteins.
Bibliography:Application Number: AU20240200321