COMPOUNDS AND METHODS FOR DEGRADING CASEIN KINASE 1 ALPHA

Provided are novel compounds represented by Formula (I) which degrade CK1α (casein kinase 1 alpha), and methods of degrading CK1α, or preventing or treating blood cancer by administering the compounds to a subject in need thereof.

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Bibliographic Details
Main Authors JO, Hyunsun, KIM, Purum, DENINNO, Michael Paul, PARK, Jisu, CHUNG, Jun-Jae, PARK, Yuna, TERRETT, Nicholas Kenneth, LEVY, Daniel Emil, KING-UNDERWOOD, John, MOHANTY, Sarina, JAIPURI, Firoz Ali
Format Patent
LanguageEnglish
Published 17.10.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are novel compounds represented by Formula (I) which degrade CK1α (casein kinase 1 alpha), and methods of degrading CK1α, or preventing or treating blood cancer by administering the compounds to a subject in need thereof.
Bibliography:Application Number: AU20230301691