TGF-beta receptor type II fusion proteins and uses thereof

Abstract In certain aspects, the present disclosure relates to TBRII fusion polypeptides comprising a heterologous portion and a tnmcated, ligand-binding portion of the extracellular domain ofTBRII polypeptide useful to selectively antagonize a TBRII ligand. The disclosure further provides compositi...

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Bibliographic Details
Main Authors SAKO, Dianne S, KUMAR, Ravindra
Format Patent
LanguageEnglish
Published 15.08.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Abstract In certain aspects, the present disclosure relates to TBRII fusion polypeptides comprising a heterologous portion and a tnmcated, ligand-binding portion of the extracellular domain ofTBRII polypeptide useful to selectively antagonize a TBRII ligand. The disclosure further provides compositions and methods for use in treating or preventing TGFB associated disorders.
Bibliography:Application Number: AU20230200218