7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS

7H-Pyrrolo[2,3-d]pyrimidine compounds of Formula (I) for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 7H-pyrrolo[2,3-d]pyrimidine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of D...

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Main Authors MAK, Chi Ching, KUMAR KC, Sunil, TURNER, Lewis Daniel, CHIRUTA, Chandramouli, HOFILENA, Brian Joseph, VAKITI, Ramkrishna Reddy, MITTAPALLI, Gopi Kumar, EASTMAN, Brian Walter, MARAKOVITS, Joseph Timothy
Format Patent
LanguageEnglish
Published 02.05.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:7H-Pyrrolo[2,3-d]pyrimidine compounds of Formula (I) for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 7H-pyrrolo[2,3-d]pyrimidine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRKIA (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).
Bibliography:Application Number: AU20220367221