COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF ANGIOPOIETIN-LIKE 3 (ANGPTL3) PROTEIN

• Main Authors: SHAO, Pengcheng Patrick, SHU, Dongxu
• Format: Patent
• Language: English
• Published: 21.03.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Compositions and methods useful to reduce expression of Angiopoietin-like 3 (ANGPTL3) gene and for treatment of ANGPTL3-associated diseases and conditions are provided. Provided are ANGPTL3 dsRNA agents, ANGPTL3 antisense polynucleotide agents, compositions comprising ANGPTL3 dsRNA agents, and, comp...