HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions...

Full description

Saved in:
Bibliographic Details
Main Authors NAVARATNE, Primali, MANONI, Francesco, LANMAN, Brian Alan, ZHAO, Wei, YAMANO, Michael M, STELLWAGEN, John, PETTUS, Liping, RAHIMOFF, Rene, WURZ, Ryan Paul, CHEN, Ning
Format Patent
LanguageEnglish
Published 15.02.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
Bibliography:Application Number: AU20220325858