RECOMBINANT ANTIGEN FOR INDUCING AN IMMUNE RESPONSE AGAINST THE ZIKA VIRUS

The invention relates to a recombinant chimeric antigen comprising, in the polypeptide chain thereof, a polypeptide corresponding to amino acids 2 to 104 of the Zika virus capsid protein or a polypeptide with an amino acid sequence with at least 90% identity with said region of the capsid protein. T...

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Main Authors ROMERO FERNÁNDEZ, Yaremis, PÉREZ FUENTES, Yusleidi, GUILLEN NIETO, Gerardo, HERMIDA CRUZ, Lisset, VALDÉS PRADO, Iris, GIL GONZALEZ, Lázaro, BRUNO DARDER, Andy, COBAS ACOSTA, Karem, SUZARTE PORTAL, Edith, LAZO VÁZQUEZ, Laura
Format Patent
LanguageEnglish
Published 15.02.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a recombinant chimeric antigen comprising, in the polypeptide chain thereof, a polypeptide corresponding to amino acids 2 to 104 of the Zika virus capsid protein or a polypeptide with an amino acid sequence with at least 90% identity with said region of the capsid protein. The invention also relates to a vaccine composition comprising said recombinant chimeric antigen and a pharmaceutically acceptable vaccine adjuvant. The invention further relates to the use of the recombinant chimeric antigen, comprising, in the polypeptide chain thereof, a polypeptide corresponding to amino acids 2 to 104 of the Zika virus capsid protein or an amino acid sequence with at least 90% identity with said segment for the production of a drug for inducing an immune response against the Zika virus. The invention also discloses a method for inducing an immune response against the Zika virus, in which the recombinant chimeric antigen is administered.
Bibliography:Application Number: AU20220320680