PROCESSES FOR THE PREPARATION OF (S)-2-(2,6-DIOXOPIPERIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL) METHYL)BENZYL) AMINO)ISOINDOLINE-1,3-DIONE

Provided herein are processes for the preparation of (S)-2-(2,6-dioxopipelidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl) methyl) benzyl)amino)isoindoline-1, 3-dione, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof, which is useful for treating, preven...

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Main Authors TAVARES-GRECO, Paula, CARRASQUILLO-FLORES, Ronald, KOTHARE, Mohit, DEL VALLE, David, PURDUM, Geoffrey, HEID, Richard, LIU, Wei, KASSIM, Amude, CORONA, Patrick, EMMANUEL, Megan, YONG, Kelvin, FERRETTI, Antonio, CHEN, Jian, DUNN, Robert, ZHANG, Chengmin, RANGANATHAN, Krishnakumar, YU, Yong
Format Patent
LanguageEnglish
Published 16.11.2023
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Provided herein are processes for the preparation of (S)-2-(2,6-dioxopipelidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl) methyl) benzyl)amino)isoindoline-1, 3-dione, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof, which is useful for treating, preventing, and managing various disorders. Also provided are solid forms of various intermediates and products obtained from the processes.
Bibliography:Application Number: AU20220300184