Macrocyclic compound and uses thereof

Abstract The present application provides a macrocyclic compound (1), and it's isotopically labelled derivatives, and also pharmaceutical compositions thereof, having tumor vascular remodelling effects and/or anti-CAF (Cancer Associated Fibroblasts) activity. The application also discloses inte...

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Bibliographic Details
Main Authors Kishi, Yoshito, Kira, Kazunobu, Ito, Ken
Format Patent
LanguageEnglish
Published 16.02.2023
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Abstract The present application provides a macrocyclic compound (1), and it's isotopically labelled derivatives, and also pharmaceutical compositions thereof, having tumor vascular remodelling effects and/or anti-CAF (Cancer Associated Fibroblasts) activity. The application also discloses intermediates in making the same.
Bibliography:Application Number: AU20220291454