SUBSTITUTED TETRAHYDROFURAN ANALOGS AS MODULATORS OF SODIUM CHANNELS

Compounds of formula I, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable sal...

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Main Authors SKERRATT, Sarah, CARVALHO MEIRELES, Lidio Marx, SHAW, David Matthew, PONTILLO, Joseph, FRAYSSE, Damien, GALAN, Bhairavi, MUI, James Jun Bon, STAMOS, Dean, CHUDYK, Ewa Iwona, GEDDIS, Stephen Michael, PULLIN, Robert, KNEGTEL, Ronald Marcellus, SCHMIDT, Yvonne, AUSTIN, James Robert, JACQUES, Reece, NORTH, Kiri, ETXEBARRIA JARDI, Gorka, HURLEY, Dennis James, HADIDA RUAH, Sara S, NEUBERT, Timothy Donald, BECK, Elizabeth Mary, STORCK, Pierre-Henri, THOMSON, Stephen Andrew, VIRANI, Anisa Nizarali, AHMAD, Nadia M, KINTZER, Alexander, DURRANT, Steven John, PINDER, Joanne Louise, WRAY, Christopher, SOUSA, Bruno Artur
Format Patent
LanguageEnglish
Published 30.11.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Compounds of formula I, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
AbstractList Compounds of formula I, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
Author KINTZER, Alexander
SKERRATT, Sarah
WRAY, Christopher
PINDER, Joanne Louise
THOMSON, Stephen Andrew
CARVALHO MEIRELES, Lidio Marx
STAMOS, Dean
AHMAD, Nadia M
CHUDYK, Ewa Iwona
JACQUES, Reece
BECK, Elizabeth Mary
SOUSA, Bruno Artur
GEDDIS, Stephen Michael
SCHMIDT, Yvonne
KNEGTEL, Ronald Marcellus
AUSTIN, James Robert
GALAN, Bhairavi
HURLEY, Dennis James
STORCK, Pierre-Henri
PONTILLO, Joseph
NORTH, Kiri
PULLIN, Robert
FRAYSSE, Damien
VIRANI, Anisa Nizarali
ETXEBARRIA JARDI, Gorka
SHAW, David Matthew
HADIDA RUAH, Sara S
DURRANT, Steven John
MUI, James Jun Bon
NEUBERT, Timothy Donald
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– fullname: SHAW, David Matthew
– fullname: PONTILLO, Joseph
– fullname: FRAYSSE, Damien
– fullname: GALAN, Bhairavi
– fullname: MUI, James Jun Bon
– fullname: STAMOS, Dean
– fullname: CHUDYK, Ewa Iwona
– fullname: GEDDIS, Stephen Michael
– fullname: PULLIN, Robert
– fullname: KNEGTEL, Ronald Marcellus
– fullname: SCHMIDT, Yvonne
– fullname: AUSTIN, James Robert
– fullname: JACQUES, Reece
– fullname: NORTH, Kiri
– fullname: ETXEBARRIA JARDI, Gorka
– fullname: HURLEY, Dennis James
– fullname: HADIDA RUAH, Sara S
– fullname: NEUBERT, Timothy Donald
– fullname: BECK, Elizabeth Mary
– fullname: STORCK, Pierre-Henri
– fullname: THOMSON, Stephen Andrew
– fullname: VIRANI, Anisa Nizarali
– fullname: AHMAD, Nadia M
– fullname: KINTZER, Alexander
– fullname: DURRANT, Steven John
– fullname: PINDER, Joanne Louise
– fullname: WRAY, Christopher
– fullname: SOUSA, Bruno Artur
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Snippet Compounds of formula I, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title SUBSTITUTED TETRAHYDROFURAN ANALOGS AS MODULATORS OF SODIUM CHANNELS
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