SUBSTITUTED TETRAHYDROFURAN ANALOGS AS MODULATORS OF SODIUM CHANNELS

Compounds of formula I, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable sal...

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Main Authors SKERRATT, Sarah, CARVALHO MEIRELES, Lidio Marx, SHAW, David Matthew, PONTILLO, Joseph, FRAYSSE, Damien, GALAN, Bhairavi, MUI, James Jun Bon, STAMOS, Dean, CHUDYK, Ewa Iwona, GEDDIS, Stephen Michael, PULLIN, Robert, KNEGTEL, Ronald Marcellus, SCHMIDT, Yvonne, AUSTIN, James Robert, JACQUES, Reece, NORTH, Kiri, ETXEBARRIA JARDI, Gorka, HURLEY, Dennis James, HADIDA RUAH, Sara S, NEUBERT, Timothy Donald, BECK, Elizabeth Mary, STORCK, Pierre-Henri, THOMSON, Stephen Andrew, VIRANI, Anisa Nizarali, AHMAD, Nadia M, KINTZER, Alexander, DURRANT, Steven John, PINDER, Joanne Louise, WRAY, Christopher, SOUSA, Bruno Artur
Format Patent
LanguageEnglish
Published 30.11.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula I, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
Bibliography:Application Number: AU20220285758