TISSUE-SPECIFIC NUCLEIC ACID DELIVERY BY MIXED CATIONIC LIPID PARTICLES

The instant disclosure relates to nucleic acid-lipid particles that mix ionizable and cationic lipids, which preferentially localize and deliver associated cargoes to the liver when administered parenterally, and which optionally can be used to deliver associated cargoes to tissues to which such par...

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Bibliographic Details
Main Authors SARISOZEN, Can, FERREIRA GOMES COSTA, Daniel, PATIL, Vishwesh Ashok
Format Patent
LanguageEnglish
Published 12.10.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The instant disclosure relates to nucleic acid-lipid particles that mix ionizable and cationic lipids, which preferentially localize and deliver associated cargoes to the liver when administered parenterally, and which optionally can be used to deliver associated cargoes to tissues to which such particles are directly injected. The instant disclosure provides compositions comprising such lipid particles, optionally in association with a therapeutic agent (
Bibliography:Application Number: AU20220262355