PHARMACEUTICAL POLYMER CONJUGATES

The present invention relates to compositions for the intracellular delivery of therapeutically active divalent metal ions, the compositions comprising a polypeptide having (i) one or more targeting moiety conjugated thereto, (ii) an ionophore conjugated thereto via a cleavable linker, and (iii) a d...

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Bibliographic Details
Main Author CHUNG, Jinhyuk Fred
Format Patent
LanguageEnglish
Published 05.10.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compositions for the intracellular delivery of therapeutically active divalent metal ions, the compositions comprising a polypeptide having (i) one or more targeting moiety conjugated thereto, (ii) an ionophore conjugated thereto via a cleavable linker, and (iii) a divalent metal ion bound thereto, and methods for preparing such compositions, and their use in therapeutic methods.
Bibliography:Application Number: AU20220238686