3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

The present disclosure provides a compound of Formula (I'): (RX)q N 3 0 R2 n (I'), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R 1, R2 , R, X1, n, nl, and q are as defined herein, and methods of making and use 5 for the treat...

Full description

Saved in:
Bibliographic Details
Main Authors Tichkule, Ritesh Bhanudasji, Visser, Michael Scott, Bonazzi, Simone, Fazal, Aleem, Cernijenko, Artiom, Beckwith, Rohan Eric John
Format Patent
LanguageEnglish
Published 06.10.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

Abstract The present disclosure provides a compound of Formula (I'): (RX)q N 3 0 R2 n (I'), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R 1, R2 , R, X1, n, nl, and q are as defined herein, and methods of making and use 5 for the treatment of IKAROS Family Zinc Finger 2 (IKZF2)-dependent diseases or disorders or where reduction of IKZF2 or IKZF4 protein levels can ameliorate a disease or disorder.
AbstractList The present disclosure provides a compound of Formula (I'): (RX)q N 3 0 R2 n (I'), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R 1, R2 , R, X1, n, nl, and q are as defined herein, and methods of making and use 5 for the treatment of IKAROS Family Zinc Finger 2 (IKZF2)-dependent diseases or disorders or where reduction of IKZF2 or IKZF4 protein levels can ameliorate a disease or disorder.
Author Tichkule, Ritesh Bhanudasji
Bonazzi, Simone
Beckwith, Rohan Eric John
Cernijenko, Artiom
Visser, Michael Scott
Fazal, Aleem
Author_xml – fullname: Tichkule, Ritesh Bhanudasji
– fullname: Visser, Michael Scott
– fullname: Bonazzi, Simone
– fullname: Fazal, Aleem
– fullname: Cernijenko, Artiom
– fullname: Beckwith, Rohan Eric John
BookMark eNqNissKwjAQAHPQg69_CHhRcKFJoJ6LKHrXcwlmSxfKbmhi0b83Bz_A0wzDLNWMhXGhbg52BuQtlIQ4yEAMFj7DPlLEkQIxgj3UEKjsOpQ0-UwTJu056FcqknscUbq1mnd-SLj5caW2l_P9dAWM0mKK_omMuW0etrLWOlMfq8a4_64vG6I16g
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID AU2022231670A1
GroupedDBID EVB
ID FETCH-epo_espacenet_AU2022231670A13
IEDL.DBID EVB
IngestDate Fri Jul 19 12:54:14 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_AU2022231670A13
Notes Application Number: AU20220231670
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221006&DB=EPODOC&CC=AU&NR=2022231670A1
ParticipantIDs epo_espacenet_AU2022231670A1
PublicationCentury 2000
PublicationDate 20221006
PublicationDateYYYYMMDD 2022-10-06
PublicationDate_xml – month: 10
  year: 2022
  text: 20221006
  day: 06
PublicationDecade 2020
PublicationYear 2022
RelatedCompanies NOVARTIS AG
RelatedCompanies_xml – name: NOVARTIS AG
Score 3.4243689
Snippet The present disclosure provides a compound of Formula (I'): (RX)q N 3 0 R2 n (I'), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug,...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221006&DB=EPODOC&locale=&CC=AU&NR=2022231670A1
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_GFPVNp-LHlIJSFAzGNu2ahyFbP5jCPpBN9jbapoPCaIft_PjvvYRO97S35AJHErjc_ZK7XwBuIytEtxILQm3uEGaIkHBLcDLnzGEs4jGlssC5P7B7E_Y6taY1WKxrYRRP6JciR0SLitHeS3VeL_8vsTyVW1k8RimK8udg3Pb0Ch0bCGCorXvdtj8aekNXd11EkvrgTY0ZsuqbdhAr7chAWjLt--9dWZey3HQqwSHsjlBfVh5BLckasO-u_15rwF6_evLGZmV9xTG8mOTuieTfeVrkCKXldzvEID-L-2Uq-YrRCyXEeLCJkOxDmkDRp6L1LrQwE9qqwIYM95J8fgI3gT92ewTnNPvbgllnsrkA8xTqGWo6A01YIQZAFHFm1GJhS3An5olwYsYsMzZpdA7NbZoutg9fwoHsquQ1uwn18mOVXKETLqNrtXe_pduJRQ
link.rule.ids 230,309,786,891,25594,76906
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_GFOebTsWPqQWlKBiMbdo1D0O2dmPTfSGb7K20TQeD0Q7b-fHfewmb7mlvRw6O5OBy90tyvwDchlaAaSUShNrcIcwQAeGW4GTKmcNYyCNKZYNzr2-3x-xlYk0KMF_3wiie0C9FjogRFWG852q_XvwfYnnqbWX2GM5wKH1ujWqevkLHBgIYauteo9YcDryBq7suIkm9_6Z0huz6pnXESjtVyc8ri6f3huxLWWwmldYB7A7RXpIfQiFOylBy13-vlWGvt7ryRnEVfdkRdExy90TS73SWpQil5Xc7xCA_8_vFTPIVYxaKifFgEyHZhzSBQ5-K1jvTgkRoywwFWe7F6fQYblrNkdsmOCf_zwV-fby5APMEiglaOgVNWAEWQBRxZlhlQVVwJ-KxcCLGLDMyaXgGlW2Wzrerr6HUHvW6frfTf72AfalSD9nsChTzj2V8iQk5D6-UH38BOm2MMg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=3-%281-oxoisoindolin-2-yl%29piperidine-2%2C6-dione+derivatives+and+uses+thereof&rft.inventor=Tichkule%2C+Ritesh+Bhanudasji&rft.inventor=Visser%2C+Michael+Scott&rft.inventor=Bonazzi%2C+Simone&rft.inventor=Fazal%2C+Aleem&rft.inventor=Cernijenko%2C+Artiom&rft.inventor=Beckwith%2C+Rohan+Eric+John&rft.date=2022-10-06&rft.externalDBID=A1&rft.externalDocID=AU2022231670A1