3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

The present disclosure provides a compound of Formula (I'): (RX)q N 3 0 R2 n (I'), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R 1, R2 , R, X1, n, nl, and q are as defined herein, and methods of making and use 5 for the treat...

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Bibliographic Details
Main Authors Tichkule, Ritesh Bhanudasji, Visser, Michael Scott, Bonazzi, Simone, Fazal, Aleem, Cernijenko, Artiom, Beckwith, Rohan Eric John
Format Patent
LanguageEnglish
Published 06.10.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure provides a compound of Formula (I'): (RX)q N 3 0 R2 n (I'), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R 1, R2 , R, X1, n, nl, and q are as defined herein, and methods of making and use 5 for the treatment of IKAROS Family Zinc Finger 2 (IKZF2)-dependent diseases or disorders or where reduction of IKZF2 or IKZF4 protein levels can ameliorate a disease or disorder.
Bibliography:Application Number: AU20220231670