Targeting Degradable Nano-Drug Carrier for Chemo/Photothermal Synergistic Therapy and Preparation Method Thereof

• Main Authors: Yang, Yiping, Lin, Fuli, Li, Wenjuan, Cui, Lin, Meng, Guihua, Liu, Zhiyong, Wu, Jianning, Yang, Shengchao
• Format: Patent
• Language: English
• Published: 13.04.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Abstract The present invention discloses a targeting degradable nanometer drug carrier for optic-thermal collaborative chemotherapy and a preparation method thereof The preparation method of the targeting degradable nanometer drug carrier for optic-thermal collaborative chemotherapy comprises: (1) preparing polydopamine-doped mesoporous silica; (2) conducting amination modification on the polydopamine-doped mesoporous silica; (3) loading an anti-cancer drug; (4) conducting modification by using activated carboxymethyl chitosan and folic acid in sequence; and (5) dispersing a product in the step (4) into a PBS solution, and conducting filtering to obtain the targeting degradable nanometer drug carrier for optic-thermal collaborative chemotherapy. For the targeting degradable nanometer drug carrier for optic-thermal collaborative chemotherapy and the preparation method thereof of the present invention, the drug carrier has high biocompatibility, degradability and targeting characteristic and is an effective way of improving the effect of treating tumors.