A conjugate of a tubulysin analog with branched linkers

• Main Authors: ZHAO, Robert Yongxin, LI, Wenjun, GAI, Shun, ZHUO, Xiaotao, ZHENG, Jun, HUANG, Yuanyuan, JIA, Junxiang, YANG, Qingliang, ZHANG, Xiuzheng, CAI, Xiang, ZHOU, Xiaomai, GUO, Huihui, XU, Yifang, LEI, Jun, TONG, Qianqian, ZHAO, Linyao, XIE, Hongsheng, YE, Hangbo, BAI, Lu, CAO, Mingjun
• Format: Patent
• Language: English
• Published: 11.07.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched linkage method of conjugation of a...