A conjugate of a tubulysin analog with branched linkers
The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched linkage method of conjugation of a...
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Main Authors | , , , , , , , , , , , , , , , , , , , |
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Format | Patent |
Language | English |
Published |
11.07.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease. |
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Bibliography: | Application Number: AU20220205269 |