Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET Kinases

Provided herein are compounds of the Formula I: R2 -NO and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R, R 2, R9, X 1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention...

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Bibliographic Details
Main Authors HINKLIN, Ronald Jay, ALLEN, Shelley, LAIRD, Ellen, COOK, Adam, NULTY, Oren T, BARBOUR, Patrick, ZHAO, Qian, DAHLKE, Joshua, GAUDINO, John
Format Patent
LanguageEnglish
Published 03.08.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compounds of the Formula I: R2 -NO and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R, R 2, R9, X 1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.
Bibliography:Application Number: AU20220202946