Macrocyclic broad spectrum antibiotics

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 5 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for...

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Main Authors ROBERTS, Tucker Curran, HIGUCHI, Robert I, BLENCH, Toby, McCLEOD, Calum, CRAWFORD, James John, LY, Cuong Q, PARASELLI, Prasuna, HU, Huiyong, YU, Zhiyong, KOEHLER, Michael F. T, HANAN, Emily J, CHEN, Yongsheng, WINSHIP, Paul Colin Michael, SMITH, Peter Andrew, SCHWARZ, Jacob Bradley
Format Patent
LanguageEnglish
Published 21.03.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 5 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
Bibliography:Application Number: AU20220201724