Inhibitors of KEAP1-Nrf2 protein-protein interaction

Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and 5 conditions associated with the KEAP1-Nrf2 interaction, such as inflammatory bowel disease, including Crohn's disease a...

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Main Authors WEI, Jianmei, CHAI, Wenying, KUMMER, David A, VENABLE, Jennifer D, HIRST, Gavin C, MCCLURE, Kelly J, BARBAY, Kent J, NISHIMURA, Rachel T, KREUTTER, Kevin D, SHIH, Amy Y, VENKATESAN, Hariharan
Format Patent
LanguageEnglish
Published 21.04.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and 5 conditions associated with the KEAP1-Nrf2 interaction, such as inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
Bibliography:Application Number: AU20220200478