CRYSTAL FORM OF CASEIN KINASE 1ε INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Disclosed is a crystal form of a casein kinase 1ε inhibitor, a method for preparing the crystal form and the use thereof. Specifically, the present invention relates to a crystal form of the compound (S)-2-(1-(4-amino-3-(2,3-difluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-...

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Bibliographic Details
Main Authors ZHOU, Xinglu, HU, Miao, WU, Yizhe, LIU, Xingguo, ZHU, Jianrong
Format Patent
LanguageEnglish
Published 22.06.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is a crystal form of a casein kinase 1ε inhibitor, a method for preparing the crystal form and the use thereof. Specifically, the present invention relates to a crystal form of the compound (S)-2-(1-(4-amino-3-(2,3-difluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-3-phenylquinazoline-4(3H)one methanesulfonate, a method for preparing the crystal form, and the use thereof. The crystal form of the compound casein kinase 1ε inhibitor compound of the present invention has a good water solubility and oral absorption, and can be effectively used for the treatment of malignant tumors and autoimmune diseases that benefit from the inhibition of casein kinase 1ε activity.
Bibliography:Application Number: AU20210407012