PH-DEPENDENT MUTANT INTERLEUKIN-2 POLYPEPTIDES

The present invention generally relates to pH-dependent mutant interleukin-2 polypeptides that exhibit reduced IL-2 receptor binding at neutral pH and retaine IL-2 receptor binding at reduced pH. In addition, the invention relates to immunoconjugates comprising said pH- dependent mutant IL-2 polypep...

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Main Authors OBBA, Melanie, GASSNER, Christian, HOSSE, Ralf, HOFER, Thomas, KLEIN, Christian, HUGENMATTER, Adrian, LIMANI, Florian, DEHÒ, Lorenzo, SCHERER, Bianca, UMAÑA, Pablo, MOESSNER, Ekkehard, HERTER, Sylvia
Format Patent
LanguageEnglish
Published 18.05.2023
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention generally relates to pH-dependent mutant interleukin-2 polypeptides that exhibit reduced IL-2 receptor binding at neutral pH and retaine IL-2 receptor binding at reduced pH. In addition, the invention relates to immunoconjugates comprising said pH- dependent mutant IL-2 polypeptides, polynucleotide molecules encoding the pH-dependent mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the pH- dependent mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
Bibliography:Application Number: AU20210393752