CONTROLLED RELEASE FILL COMPOSITIONS AND CAPSULES CONTAINING SAME

A controlled release fill composition for use in soft or hard capsules, soft- or hard-shell capsules encapsulating controlled release fill compositions, a method of producing a softgel capsule with a controlled release fill composition encapsulated in the soft gel capsule shell. The controlled relea...

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Bibliographic Details
Main Authors FANG, Qi, SUKURU, Karunakar
Format Patent
LanguageEnglish
Published 01.06.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A controlled release fill composition for use in soft or hard capsules, soft- or hard-shell capsules encapsulating controlled release fill compositions, a method of producing a softgel capsule with a controlled release fill composition encapsulated in the soft gel capsule shell. The controlled release fill composition includes an active pharmaceutical ingredient; polyethylene oxide having a number average molecule weight of from 0.05 M daltons to 15 M daltons; and at least one of water or a hydrophilic carrier having a number average molecule weight of from 200 daltons to 5000 daltons. Also, in the controlled release fill composition either the polyethylene oxide is present in an amount of at least 21.5 wt.%, based on a total weight of the controlled release fill composition, or the hydrophilic carrier is present in an amount up to 65 wt.%, based on a total weight of the controlled release fill composition.
Bibliography:Application Number: AU20210360905