MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharma...

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Main Authors KHATUYA, Haripada, HADIDA RUAH, Sara Sabina, MCCARTNEY, Jason, CLEVELAND, Thomas, FANNING, Lev Tyler Dewey, ABRAHAM, Sunny, SILINA, Alina, KRENITSKY, Paul, PIERRE, Fabrice, COON, Timothy Richard, VALDEZ, Lino, ISHIHARA, Yoshihiro, ZHOU, Jinglan, VICKERS, Troy, PARASELLI, Prasuna, MILLER, Mark Thomas, ARUMUGAM, Vijayalaksmi, TRAN, Joe A, DWIGHT, Timothy A, GROOTENHUIS, Peter, FRIEMAN, Bryan A, ANDERSON, Corey Don, UY, Johnny, MELILLO, Vito, CLEMENS, Jeremy, ABELA, Alexander Russell, CHAU, Jaclyn, GULEVICH, Anton V
Format Patent
LanguageEnglish
Published 24.10.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.
Bibliography:Application Number: AU20210358512