Anti-human vista antibodies and use thereof

The invention provides anti-VISTA antibody drug conjugates which may be used for targeted delivery of anti-inflammatory agents such as steroids to immune cells, e.g., myeloid cells. The invention also provides methods of using anti-VISTA antibody drug conjugates in the treatment of inflammatory and/...

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Main Authors KLINE, Toni, CARRIERE, Catherine, MOLLOY, Michael, ROTHSTEIN, Jay, KUTA, Anna, LORIYA, Rajeshkumar Maganlal, MEIMETIS, Labros, MEDINA, Julio, THUMMANAPELLI, Sravan, PECHENICK, Dov, CLARK, Erin, KOVAL, Alexander, SCHWERTNER, Nicholas, SUN, Sheng, WANG, Yingcai (Ian), BORKIN, Dmitry, BELL, Kierstin, RAJANNA, Shibhani, SEREGIN, Sergey, DAY, Maria, GUO, Yalin, HUANG, Xin, ZHOU, Jieyu
Format Patent
LanguageEnglish
Published 05.01.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention provides anti-VISTA antibody drug conjugates which may be used for targeted delivery of anti-inflammatory agents such as steroids to immune cells, e.g., myeloid cells. The invention also provides methods of using anti-VISTA antibody drug conjugates in the treatment of inflammatory and/or autoimmune conditions and/or for alleviating the toxicity of anti-inflammatory agents such as steroids.
Bibliography:Application Number: AU20210261386