Pegylated Porcine Interferon and Methods of Use Thereof

Disclosed herein are porcine interferon alpha variants (pNF-a) comprising a synthetic amino acid at select locations in 0 pNF-a and a one or two amino acid insertion in the N-terminus after removal of the signal peptide. The pNF-a variants can further be pegylated. Methods of making and administerin...

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Bibliographic Details
Main Authors Canning, Peter Connor, Skidmore, Lillian, Knudsen, Nickolas
Format Patent
LanguageEnglish
Published 30.09.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed herein are porcine interferon alpha variants (pNF-a) comprising a synthetic amino acid at select locations in 0 pNF-a and a one or two amino acid insertion in the N-terminus after removal of the signal peptide. The pNF-a variants can further be pegylated. Methods of making and administering these compounds to treat virus infections in pigs and formulations comprising the variants are also provided.
Bibliography:Application Number: AU20210229132