Sodium 2- [(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)- phenyl]-4H-quinazolin-4-yl]acetate and pharmaceutical compositions thereof

The present invention relates to new stable pharmaceutical compositions containing sodium 2- [(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)- phenyl]-4H-quinazolin-4-yl]acetate that are essentially free of complexing solubilizing agents, such as PEG, cyclodextri...

Full description

Saved in:
Bibliographic Details
Main Authors BUSCHMANN, Helmut, REDMER, Jessica, HAWE, Andrea, GOLDNER, Thomas, ROSA, Monica, LUCKE, Matthias, HOHMANN, Dorothea
Format Patent
LanguageEnglish
Published 19.09.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The present invention relates to new stable pharmaceutical compositions containing sodium 2- [(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)- phenyl]-4H-quinazolin-4-yl]acetate that are essentially free of complexing solubilizing agents, such as PEG, cyclodextrin, lysin, arginine, in particular HPBCD. The invention further relates to methods of preparation of said pharmaceutical compositions. The invention further relates to use of said pharmaceutical compositions in methods of treatment of and/or as a prophylactic for illnesses, particularly its use as an antiviral, preferably against cytomegaloviruses.
Bibliography:Application Number: AU20210228240