Improvement of expression and folding in the manufacturing process of CD-RAP by using a CD-RAP precursor protein

Improvement of expression and folding in the manufacturing process of CD-RAP by using a CD-RAP precursor protein Abstract The present invention relates to a CD-RAP precursor protein comprising a pre-sequence and CD-RAP, and its use in manufacturing of native CD-RAP. The present invention further rel...

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Main Authors JANOCHA, Bernd, BARTNIK, Eckart, STOMMES, Judith, HABERMANN, Paul, SAAS, Joachim, SCHOETTLE, Isabell, STILLGER, Ursula, JESKE, Volker
Format Patent
LanguageEnglish
Published 06.05.2021
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Summary:Improvement of expression and folding in the manufacturing process of CD-RAP by using a CD-RAP precursor protein Abstract The present invention relates to a CD-RAP precursor protein comprising a pre-sequence and CD-RAP, and its use in manufacturing of native CD-RAP. The present invention further relates to a composition comprising CD-RAP and at least one positively charged amino acid and a buffer, pharmaceuticals comprising said composition, their use in methods of treating and/or preventing cartilage disease or injury in patients suffering from aggrecan degradation, and/or increased influx of water into the cartilage, and/or decreased CD-RAP expression, as well as methods of producing said composition and methods of storing CD RAP in said composition. The present invention further relates to a composition comprising liposomes comprising encapsulated CD-RAP or a variant thereof, its use in methods of treating joint disease or injury, and methods of producing such liposomal composition as well as storing CD-RAP therein.
Bibliography:Application Number: AU20210202110