Pyrazole derivatives as plasma kallikrein inhibitors

Abstract The present invention provides a selection of compounds of formula (1) and includes compositions comprising such compounds, the use of such compounds in therapy (for example in the treatment or prevention of disease or condition in which plasma kallikrein activity is implicated), and method...

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Bibliographic Details
Main Authors Davie, Rebecca Louise, Hodgson, Simon Teanby, Pethen, Stephen John, Edwards, Hannah Joy, Evans, David Michael, Rooker, David Philip
Format Patent
LanguageEnglish
Published 02.06.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Abstract The present invention provides a selection of compounds of formula (1) and includes compositions comprising such compounds, the use of such compounds in therapy (for example in the treatment or prevention of disease or condition in which plasma kallikrein activity is implicated), and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein. O&Z-R5 Formula (1)
Bibliography:Application Number: AU20210200140