Conjugates of a cell-binding molecule with camptothecin analogs

Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and --- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjug...

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Main Authors LI, Wenjun, GUO, Zhixiang, HUANG, Yuanyuan, ZHAO, Robert, ZHENG, Wei, YANG, Qingliang, CAI, Xiang, HUANG, Shangma, CHEN, Xiaoxiao, WANG, Xiaoxu, YE, Hangbo, CHEN, Diancheng, ZHANG, Lingli, ZHANG, Xiuzhen, LI, Yanhua, ZHENG, Jun, ZHAO, Gengxiang, CHEN, Miaomiao, JIA, Junxiang, JIANG, Xinyan, GUO, Huihui, XU, Yifang, DU, Yong, LIN, Chen, YE, Riping, KONG, Xiangfei, ZHENG, Yunxia, BAI, Lu
Format Patent
LanguageEnglish
Published 02.02.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and --- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.
Bibliography:Application Number: AU20200444233