Magnetic tracer compositions

• Main Authors: THIERRY, Benjamin, COUSINS, Aidan, HAWKETT, Brian Stanley, NELSON, Melanie Ruth Maria, BARTLETT, Stewart Gavin, PHAM, Thi Hanh Nguyen
• Format: Patent
• Language: English
• Published: 02.09.2021
• Subjects: DIAGNOSIS; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SURGERY

Disclosed herein are pharmacologically acceptable magnetic nanoparticles suitable for administration to a subject. The magnetic nanoparticles have a pharmacologically acceptable polymer composition coating. The polymer composition coating comprises a polymeric steric stabiliser that promotes dispersion of the magnetic nanoparticles in a liquid, the polymeric steric stabiliser comprising (i) an anchoring polymer segment having one or more binding group that bind the polymeric steric stabiliser to the magnetic nanoparticles, and (ii) a steric stabilising polymer segment. The polymer composition coating also comprises:a polymeric targeting moiety comprising (i) an anchoring polymer segment having one or more binding group that bind the polymeric targeting moiety to the magnetic nanoparticles, and (ii) one or more targeting group for selectively targeting specific sites in the subject upon administration of the dispersion; and optionally a polymeric luminescent moiety comprising (i) an anchoring polymer segment having one or more binding group that bind the polymeric luminescent moiety to the magnetic nanoparticles, and (ii) one or more luminescent group for emitting light or an acoustic signal in response to light that enables in vivo location visualisation of the nanoparticles.