WDR5 inhibitors and modulators

Isoquinolmone compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

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Bibliographic Details
Main Authors LEE, Taekyu, FESIK, Stephen W, CHOWDHURY, Somenath, MEYERS, Kenneth M, TEUSCHER, Kevin B, TIAN, Jianhua
Format Patent
LanguageEnglish
Published 26.05.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Isoquinolmone compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.
Bibliography:Application Number: AU20200380828