Pyridine derivatives as KIF18A inhibitors

Amide compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical composit...

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Bibliographic Details
Main Authors BANERJEE, Abhisek, FROHN, Michael J, XUE, Qiufen May, KALLER, Matthew Richard, NGUYEN, Thomas T, CHEN, Jian Jeffrey, ALLEN, John Gordon, NISHIMURA, Nobuko, TAMAYO, Nuria A
Format Patent
LanguageEnglish
Published 17.03.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Amide compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.
Bibliography:Application Number: AU20200325115