Anti-CD53 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof

The present invention is based, in part, on the discovery of anti-CD53 compositions ( e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate inflammatory phenotypes of myeloid cells, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic c...

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Bibliographic Details
Main Authors WAHLE, Joseph A, NOVOBRANTSEVA, Tatiana I, SAZINSKY, Stephen L, FELDMAN, Igor
Format Patent
LanguageEnglish
Published 17.02.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention is based, in part, on the discovery of anti-CD53 compositions ( e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate inflammatory phenotypes of myeloid cells, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells, including polarization, activation, and/or function, and methods of using such anti-CD53 compositions for therapeutic, diagnostic, prognostic, and screening purposes.
Bibliography:Application Number: AU20200304415