Microfluidic system for intracellular delivery of substances and method therefor

Provided is a microfluidic system for delivering external substances into cells by cell perforation performed using inertia, the system comprising a fluid channel structure through which a solution containing cells and external substances continuously flows, wherein the fluid channel structure inclu...

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Bibliographic Details
Main Authors CHUNG, Aram, KANG, Gum-Young, HUR, Jeong Soo
Format Patent
LanguageEnglish
Published 21.10.2021
Subjects
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
TRANSPORTING
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Summary:Provided is a microfluidic system for delivering external substances into cells by cell perforation performed using inertia, the system comprising a fluid channel structure through which a solution containing cells and external substances continuously flows, wherein the fluid channel structure includes a junction between one or more channels, a local vortex occurs near the interface of the junction, the cells are deformed by the vortex, the vortex causes a temporary discontinuity in the cell membrane, and the external substances are introduced into the cells by solution exchange between the cells and the fluid around the cells.
Bibliography:Application Number: AU20200234406