LTBP complex-specific inhibitors of TGFβ and uses thereof

Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-ΤGFβ and/or LΤΒΡ3-ΤGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting ΤGFβ activation, and treating subjects suffering f...

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Bibliographic Details
Main Authors WAWERSIK, Stefan, JACKSON, Justin W, DATTA, Abhishek, FOGEL, Adam, SCHURPF, Thomas, CORICOR, George, LITTLEFIELD, Christopher
Format Patent
LanguageEnglish
Published 23.09.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-ΤGFβ and/or LΤΒΡ3-ΤGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting ΤGFβ activation, and treating subjects suffering from ΤGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context- dependent or context-independent isoform-specific ΤGFβ inhibitor for a subject in need thereof are also provided.
Bibliography:Application Number: AU20200216177