TRANSGENIC MICE EXPRESSING CHIMERIC MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS I MOLECULES

The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized P 2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified...

Full description

Saved in:
Bibliographic Details
Main Authors Murphy, Andrew J, Voronina, Vera, Harris, Faith, Xue, Yingzi, Macdonald, Lynn, McWhirter, John, Stevens, Sean, Gurer, Cagan
Format Patent
LanguageEnglish
Published 24.11.2022
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
CARE OF BIRDS, FISHES, INSECTS
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
NEW BREEDS OF ANIMALS
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
TRAPPING
Online AccessGet full text

Cover

More Information
Summary:The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized P 2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
Bibliography:Application Number: AU20200204410