Formulations of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methycyclohexylamino)-pyrimidine-5-carboxamide

Abstract Provided are pharmaceutical compositions and dosage forms of 2-(tert-butylamino)-4 ((IR,3R,4R)-3-hydroxy-4- methylcyclohexylamino)-pyrimidine-5-carboxamide, or a pharmaceutically acceptable stereoisomer, tautomer, solid form, poly- morph, salt, hydrate, clathrate, or solvate thereof. Also p...

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Main Authors BOERSEN, Nathan Andrew, HUANG, Lianfeng, GHOSH, Indrajit, ZOU, Daozhong
Format Patent
LanguageEnglish
Published 03.03.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Abstract Provided are pharmaceutical compositions and dosage forms of 2-(tert-butylamino)-4 ((IR,3R,4R)-3-hydroxy-4- methylcyclohexylamino)-pyrimidine-5-carboxamide, or a pharmaceutically acceptable stereoisomer, tautomer, solid form, poly- morph, salt, hydrate, clathrate, or solvate thereof. Also provided are methods of treating, managing, or preventing various disorders, such as diseases or disorders treatable or preventable by inhibition of a INK pathway in mammals using such pharmaceutical com - positions or dosage forms. Further provided are salts of 2-(tert-butylamino)-4-((IR,3R,4R)-3-hydroxy-4-methylcyclohexylamino) pyrimidine-5-carboxamide and methods of preparation of such salts.
Bibliography:Application Number: AU20200203497