Heteroaryl pyridone and aza-pyridone compounds as inhibitors of Btk activity

Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X, X2, and X3 are N, and including stereoisomers, tautomers, and 5 pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediate...

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Bibliographic Details
Main Authors CRAWFORD, James John, YOUNG, Wendy B, ORTWINE, Daniel Fred, WEI, BinQing
Format Patent
LanguageEnglish
Published 02.09.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X, X2, and X3 are N, and including stereoisomers, tautomers, and 5 pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. R4 y2 O X 1 x3 X2'
Bibliography:Application Number: AU20200202707