Method for producing oligonucleic acid compound

The purpose of the present invention is to provide a novel production method with which it is possible to shorten the production time of an oligonucleic acid compound. A method for subjecting a compound [A] having a hydroxyl group or a primary or secondary amino group and a compound [B] having a sub...

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Bibliographic Details
Main Authors KOTOBUKI, Yutaro, URABE, Fumiya
Format Patent
LanguageEnglish
Published 29.02.2024
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The purpose of the present invention is to provide a novel production method with which it is possible to shorten the production time of an oligonucleic acid compound. A method for subjecting a compound [A] having a hydroxyl group or a primary or secondary amino group and a compound [B] having a substituent that contains a phosphorus atom as represented by general formula [1] to a condensation reaction to produce a compound [C] represented by general formula [C], wherein the method is characterized by being carried out in a mixed solvent of a polar solvent and a halogen-based solvent as the reaction solvent, can be given as an example of the present invention.
Bibliography:Application Number: AU20190266768